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Growing Allergy Relief

An Australian scientist has come up with a hypoallergenic ryegrass without the major allergens that plague millions of hay fever sufferers. His collaborators in the USA hope to begin the world's first field trials on the plants in Oklahoma next year.

If the trials are successful, there may be less sniffling and sneezing in the future for Americans. The far future, admittedly: It would take as long as a decade for the public to see actual results.

Still, researcher German Spangenberg of La Trobe University in Victoria takes the long view: One day, "fewer people will suffer because of these grasses," he says.

Ryegrass, a prolific pollen producer, is a cool-season grass grown primarily across the center of the country and in the Pacific Northwest. It's also used as a winter grass in the South and as forage for grazing animals. It's a major pollen allergen in temperate climates in spring. Even where it's not a major grass variety, it causes suffering because of its heavy pollen production, Spangenberg says.

More than 50 million Americans suffer allergies. Of those, 35 million get hay fever during the March-through-August hay fever season. For 26 million of them, the primary allergen is ragweed, which isn't just one plant but a group of 17 wild weed species that are wind-pollinated, says Mike Tringale of the Asthma and Allergy Foundation of America. The other nine million are primarily allergic to grass, tree and mold pollens. However, all 35 million are likely to be at least somewhat allergic to the other kinds of pollen, so a hypoallergenic ryegrass would help them to at least some extent.

Each ryegrass pollen has five outer coats. Spangenberg and his team disarmed the first two using a technique in which the gene that produces the allergen is taken out and returned backwards.

So far, testing has shown no other effects on the grass beyond the absence of sneeze-producing proteins, Spangenberg says.

Zeng-yu Wang of the Samuel Roberts Noble Foundation in Ardmore, Okla., is the U.S. side of the team. He hopes to begin open field testing next year to see how far the pollen spreads and whether it can interbreed with other grasses to produce other non-allergen varieties.

"It's exciting work, there's no doubt about that," says Donald Pulver, an allergist with the University of Rochester in New York. But ryegrass is only part of the hay fever problem, he cautions.

"You can knock out the perennial rye, but you've still got Timothy, Kentucky blue and fescue," he says.

To give hay fever sufferers a real break you'd have to bioengineer the dozens of domesticated and wild grasses found in the USA, says Andrew Saxon, chief of UCLA's Division of Clinical Immunology and Allergy. "I'm not sure how that's going to help to take it out of just one grass."

And there are a lot of questions that would have to be answered before we'd want to be planting transgenic grass in our lawns, says Jane Rissler with the Union of Concerned Scientists. There are often unintended consequences for this kind of genetic tinkering, she says.

William Meyer of Rutgers University, a turf grass breeding expert, says a larger question is who will pay for it.

"I'm not sure how many farmers would care. It's one of those things where you'd have to do it for the good of the country."


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